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HIV Prevention Trials Network Projects

WGHI is a partner in the HIV Prevention Trials Network (HPTN), a global network of prevention science funded by the National Institute of Allergy and Infectious Disease (NIAID) at the National Institutes of Health (NIH).

Our "unit" of this network (details below), is involved in the following studies:

National Institute of
  Allergy and Infections
(at the NIH)

University of Zimbabwe
UZ-UCSF Collaborative
  Research Programme in
  Women's Health
 Zimbabwe AIDS
  Prevention Program
 San Francisco Dept. of
  Public Health

Principal Investigator
Dr. Tsungai Chipato

About our prevention trials unit

Our HIV Prevention Trials Unit (HPTU) is a collaboration between the University of Zimbabwe, the UZ-UCSF Collaborative Research Programme in Women's Health in Harare, Zimbabwe and the University of California San Francisco, the Zimbabwe AIDS Prevention Program and the HIV/AIDS Research Group at the San Francisco Department of Public Health. Dr. Tsungai Chipato from the University of Zimbabwe is the Principal Investigator for the overall program. Together, we bring the HPTN two strong research sites (one international and one domestic) and substantial expertise in epidemiology, clinical trials design, clinical medicine, behavioral science, biostatistics, virology and data management. We have strong ties with HIV-infected and at-risk populations in Zimbabwe and San Francisco, and ensure active community involvement in the planning and implementation of trials.

Even more than the fruitful collaboration between separate HPTN sites, this combined site fosters synergy and communication between investigators representing a wide range of expertise. It is cost effective because it funds investigators and staff at the combined site to work on multiple projects. The science arising from these combined sites also benefits from the broad focus brought to prevention research by the need to integrate domestic and international concerns, and to develop prevention strategies for different modes of sexual transmission. Integration of the two community advisory boards allows us to deepen our understanding, disseminate complementary skills, and ultimately enhance the contribution of affected communities to the research agenda.

Specific Aims

  • To provide scientific expertise and leadership to the network specifically in the areas of:
  1. rectal and vaginal microbicide and barrier contraceptive research;

  2. identification and implementation of interventions to reduce high-risk sexual behavior;

  3. use of anti-retroviral therapy to prevent transmission;

  4. research on prevention of perinatal transmission;

  • To conduct and participate in Phase I, II and/or III prevention intervention clinical trials domestically and internationally;

  • To convene and maintain community advisory boards in San Francisco and in Zimbabwe and to link them;

  • To demonstrate our ability to expand to multiple prevention efficacy trials in new populations.



Information: kciabattari@psg.ucsf.edu  Web site problems/comments: kciabattari@psg.ucsf.edu.
Copyright 2001, Women's Global Health Imperative, a project of the
AIDS Research Institute at the University of California, San Francisco.
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